Advanced PNL formulation

Cannabinoid molecules are subject to insolubility as well
as extensive first-pass metabolism in the gastrointestinal tract (GI), leading to a limited oral bioavailability, slow onset, and inconsistent absorption, yielding clinical and safety-related issues.

Advanced Pro-Nano Liposphere (PNL) is a patented novel self nano emulsifying drug delivery system (SNEDDS) designed to overcome those challenges and ensure rapid, efficient, controlled cannabinoid oral delivery.


Advanced PNL provides an effective delivery platform for a range of standardized cannabinoid-based products backed by several years of development and remarkable pharmacokinetic (PK) values in extensive preclinical and clinical studies, including six different scientific publications and hundreds of citations.



We solve complicated problems with

innovative yet straightforward solutions.


Trans-Mucosal Delivery Device


Trans-mucosal delivery, including buccal, sublingual, nasal,
and vaginal, is a non-invasive systemic administration that bypasses the gastrointestinal tract (GI) and avoids the
first-pass effect by directly absorbing into the blood system
the membrane.

To gain the maximum benefits of Trans-mucosal delivery, one must solve the fundamental challenge of synchronizing the release profile and the membrane’s absorption capability.


Elixie developed an applicator with a dynamic release mechanism fully compatible with the individual's anatomical demands to overcome that challenge and ensure that the drug release is adjusted for optimal delivery.