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Advanced PNL formulation
 

Cannabinoid molecules are subject to insolubility as well
as extensive first-pass metabolism in the gastrointestinal tract (GI), leading to a limited oral bioavailability, slow onset, and inconsistent absorption, yielding clinical and safety-related issues.


Advanced Pro-Nano Liposphere (PNL) is a patented novel self nano emulsifying drug delivery system (SNEDDS) designed to overcome those challenges and ensure rapid, efficient, controlled cannabinoid oral delivery.

 

Advanced PNL provides an effective delivery platform for a range of standardized cannabinoid-based products backed by several years of development and remarkable pharmacokinetic (PK) values in extensive preclinical and clinical studies, including six different scientific publications and hundreds of citations.

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Technology

We solve complicated problems with

innovative yet straightforward solutions.

 

Trans-Mucosal Delivery Device

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Trans-mucosal delivery, including buccal, sublingual, nasal,
and vaginal, is a non-invasive systemic administration that bypasses the gastrointestinal tract (GI) and avoids the
first-pass effect by directly absorbing into the blood system
the membrane.

To gain the maximum benefits of Trans-mucosal delivery, one must solve the fundamental challenge of synchronizing the release profile and the membrane’s absorption capability.

 

Elixie developed an applicator with a dynamic release mechanism fully compatible with the individual's anatomical demands to overcome that challenge and ensure that the drug release is adjusted for optimal delivery.

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